When the San Francisco 49ers marched into Nissan Stadium in 2021, they did so as 3.5-point favorites, having won five of their past six games.
They faced a banged-up Titans team, playing without Taylor Lewan, Derrick Henry and David Long, among others. Still, the Titans found a way to pull the upset, knocking off the 49ers 20-17 in front of a national television audience.
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